CSIC is the largest public institution devoted to research in Spain and the third largest in Europe. It belongs to the Spanish Ministry of Economy and Competitiveness through the Secretary of State for Research, Development and Innovation. The purpose of CSIC is the development, coordination and diffusion of multidisciplinary scientific research with the aim of contributing to the advance of the knowledge and its economic, social and cultural impact. CSIC plays an important role in the scientific and technological development of Spanish research covering an ample range from basic research to the transfer of knowledge to the productive sector. Its research is performed in its 132 centres and institutes, which are spread across all the autonomous regions, and its staff consist of more than 15,000 employees, including more than 3,000 are researchers and a similar number of doctors and scientists in training. While CSIC staff represents 6% of all the staff devoted to Research and Development in Spain, it generates around 20% of all scientific production of the country.
Dr. Mariano Carrión-Vázquez (Project Coordinator)
Education. Mariano Carrión-Vázquez studied biology (specialty of biochemistry) in the University of Valencia completing his PhD in molecular neurobiology in 1993 at the Autonomous University of Madrid. Later, in the laboratory of Prof. Julio Fernández he focused on protein nanomechanics, first as a postdoctoral student at the Mayo Clinic (Rochester, MN) and later as an assistant professor at the Columbia University (New York, NY) where he developed the methodology of polyproteins as unequivocal single-molecule markers, which greatly facilitated the later progress of the field. He also established two of the main model systems that are currently being used in the protein nanomechanics field: titin I27 module and ubiquitin.
Interests and contributions. In his group they are applying protein nanomechanics to elucidate the inner workings of a selection of proteins of particular interest in biology, medicine and industry. His group has discovered the most mechanostable proteins to date, both folded (cohesin I modules from scaffoldins) and disordered (hyper-mechanostable conformations from neurotoxic proteins); the widespread distribution in biology of the mechanical clamp motif and the nanomechanical properties of important protein modules from adhesion proteins (cadherins, cohesins).
Current research. The main current interests of his group include amyloidogenesis (both pathological and functional), neurodegeneration, memory consolidation, synaptogenesis, audition & deafness, neurotransmission and cellulosomal activity. The proteins currently investigated include neurotoxic proteins, cadherins, CPEB/Orb2 and scaffolding proteins.
Role in CellulosomePlus: he is the intermediary between the Parties and the European Commission and shall perform all tasks assigned to it as described in the Grant Agreement and in this Consortium Agreement. His group is leader of Work Packages 1 and 10 and they are mainly in charge of characterizing the nanomechanical properties of cellulosomal components (leaders of WP 3).
See more at: www.carrionvazquez-lab.org
Dr. Laura Vay
Project Manager, Cajal Institute, CSIC, Madrid, Spain
Education: Laura Vay received her bachelor degree in Biology from IE University in 2003. Later this year, she started her PhD at the Institute of Molecular Biology and Genetics (IBGM) and the University of Valladolid. Her work focused on the study of calcium homeostasis at subcellular level and the main channels involved, and in particular, on the characterization of the mitochondrial calcium uniporter (UCM) and its role in the cytosolic calcium oscillations, obtaining her PhD in May 2008.
In 2009, she did my postdoctoral period at the University of Cambridge (CAM, UK), at the Department of Pharmacology to study chronic pain and its main components. The study was focused on the characterization and purification of the thermo-receptor TRPV1, involved in the transmission of pain and heat, and a key component in the regulation of body temperature. During this period she developed and optimized protocols in order to obtain suitable amounts of the channel for subsequent crystallization studies, and included in studies on of TRPV1 membrane trafficking regulation.
In 2013, she completed a Masters in Environmental Management at the Instituto de Empresa (IE, Madrid) and afterwards, she joined Bioversity International (BI, Colombia) as junior consultant. This institution is part of CGIAR, an international research organization that brings together several institutions engaged in research, and whose scientific work aims to ensure a more sustainable management of natural resources. Later, she joined Water and Agriculture´s team at WWF-Spain (Madrid) as technical project assistant. The work involved in projects whose common goal is a sustainable management of water and soil resources in Spain.
In parallel, she was working at the consulting enterprise ICATALIST (Madrid), as junior consultant, and research associate on a study of water management in the basin of Duero, which was carried out in collaboration with FAO.
In 2013 she joined the consulting Enterprise Biomedred S.L. (Madrid) as project manager assitant. The main activities included the administrative management of research projects, mainly in the area of biomedicine, and the review and translation of scientific papers.
Role in CellulosomePlus: she is the Project Manager of the consortium, responsible for the day-to-day management of the project, and the Exploitation Manager, responsible of the project dissemination objectives in cooperation with the partner’s representatives.