The Marine Institute “Station Biologique de Roscoff”, located on the Brittany coast of the English Channel, is a research and training center in marine biology and oceanography, founded in 1872 by the Paris VI University Pierre and Marie Curie (UPMC) that also belongs to the national research center (CNRS). Its missions are both to promote research and education on the biology of marine organisms and ecosystems and to provide access, to staff and non-resident researchers, to the ecological and biological resources of the site. As a sea-front laboratory equipped with marine facilities and an integrative biology platform with dedicated staff, the SBR provides a unique scientific and technical environment for researchers, who wish to apply modern approaches to the study of marine organisms, notably micro- and macroalgae, invertebrates, and fish.
Dr. Mirjam Czjzek.
Research Director, CNRS.
Education: She is crystallographer by education and has discovered the world of CAZymes by working on crystal structures of cellulases and beta-glucosidases for several years in the group of Bernard Henrissat in Marseille, France. She has twenty years of experience in structural biology focusing on the structure/function relationship of polysaccharide degrading enzymes. She has actively participated to 5th and 6th FP European research projects EUROCELL and EDEN that aimed at understanding the synergistic enzymatic degradation of cellulose and hemicelluloses. In this context, she was involved in the elucidation of one of the first cellulase crystal structures and the first SAXS structures of mini-cellulosomes.
Interests: In 2005 she moved to the Station Biologique de Roscoff (CNRS, Centre National de Recherche Scientifique), where her research program entitled ‘marine glycobiology’ currently focuses on the structures and functions of carbohydrate-active enzymes, including their CBMs, which are involved in marine algal cell wall polysaccharide depolymerization. Her group studies the identification and the characterization of enzymes involved in the degradation, modification and the biosynthesis of the cell wall polysaccharides of plant and marine macro-algae. One particular goal is to establish the molecular bases of the protein – polysaccharide interactions, combining biochemical approaches (expression and purification of recombinant polysaccharidases from heterologous systems, directed mutagenesis, enzymology, etc) with crystal structure methods, and to dissect the 3D architecture of full length enzymes and complexes by combining crystallography with SAXS.
Role in CellulosomePlus: Characterization the atomic and supramolecular structure of candidate components by X-ray diffraction and SAXS (leader of WP 4).